Male Fertility & Urology
Half of conception.
Often half of the story.
Sperm contributes 50% of the genetic material in every embryo. At Twig, sperm providers get the full clinical attention they deserve: comprehensive testing, advanced lab techniques, and surgical sperm retrievals performed on-site by a reproductive urologist.
The Half Nobody Talks About
Male-factor fertility shapes outcomes too.
Sperm providers shape outcomes too. How easily conception happens, the quality of embryos created in IVF, the likelihood of a healthy pregnancy, and a range of long-term health outcomes for any child born are all influenced by sperm. About a third of fertility challenges are sperm-related, about a third are egg-related, and the remaining third involve factors on both sides. In a meaningful share of cases, sperm is the primary signal.
Sperm cells have a 2 to 3 month life cycle. That means what you do today, the sleep, the diet, the heat exposure, the medications, shows up in test results roughly a season from now. The corollary is hopeful: most sperm providers can meaningfully improve sperm parameters in a single quarter. Twig’s clinical team can identify where you are now and what’s worth changing. The simplest place to begin is a Fertility Check for Sperm: $250, results in a week.
Where to start
Start with a Fertility Check for Sperm.
A full semen analysis at our clinic and a 20-minute virtual review with one of our fertility specialists. $250 in both Toronto and Vancouver, no referral needed, results in about a week. You leave with a personalized report and a clear sense of where you are. The diagnostic menu below is what may come next if your results warrant deeper investigation.
Testing & Diagnostics
Diagnostics, tailored to your picture.
Not every test is for every patient. After your initial consult, your fertility specialist orders the tests that fit your situation. Many patients only need a few. Here’s the full menu of what may be involved.
Semen Analysis
The starting point. Measures volume, concentration, motility, morphology, and total motile count to assess sperm quantity and quality. Most patients access this as part of a Fertility Check for Sperm ($250), which includes a virtual specialist review.
Sperm DNA Fragmentation
Measures how damaged the DNA inside sperm is, which can affect fertilization potential and pregnancy outcomes. Not routine, but ordered based on history or prior IVF outcomes.
Hormone Testing
Targeted blood work to assess hormones that influence libido, sexual function, and sperm production: FSH, LH, estrogen, testosterone, prolactin, and thyroid.
Scrotal Ultrasound
Examines the testicles, epididymis, and scrotal veins for anatomical abnormalities that may affect fertility. Ordered based on history or semen analysis results.
Genetic Carrier Screening
Optional blood test that identifies whether you carry harmful variants in recessive genes. Includes a pre-test education session and comprehensive post-test counselling with our genetic counsellor.
Infectious Disease Screening
Standard screening before fertility treatment. Blood work for HIV, Hepatitis B, Hepatitis C, and syphilis. May include a urine screen for Chlamydia and Gonorrhea.
Sperm DNA Fragmentation Index in Toronto is performed by FlowLabs; fees payable directly to FlowLabs.
Treatments & Advanced Techniques
The full spectrum, coordinated end-to-end.
When sperm is part of the picture, the right treatment depends on the diagnostic finding. Twig handles lab techniques and on-site surgical retrieval in-house, and coordinates hospital-based microTESE with our surgical partner.
Lab technique
IVF with ICSI
IVF with ICSI (intracytoplasmic sperm injection) places a single sperm directly into each egg in our lab. ICSI dramatically improves fertilization rates when sperm counts or motility are low. IUI (intrauterine insemination) is often the first-line treatment when sperm parameters are mildly affected; ICSI is used for more significant sperm-factor diagnoses.
See IVF service detailsAdvanced lab technique
PICSI (Physiological ICSI)
PICSI is a refined version of ICSI that uses hyaluronic acid to select sperm with the highest binding capacity, a proxy for mature, well-functioning sperm with intact DNA. Research suggests PICSI may reduce early pregnancy loss, particularly when DNA fragmentation is elevated.
We may recommend PICSI if you have:
- Elevated sperm DNA fragmentation
- A history of low blastocyst formation rates
- Recurrent early pregnancy losses
PICSI is added on to an IVF cycle and discussed with your fertility specialist based on your specific history.
Surgical sperm retrieval
For obstructive azoospermia or severe ejaculatory dysfunction, sperm can be recovered surgically. PESA and TESA are performed on-site at Twig by our reproductive urologist. microTESE is performed at a hospital with our surgical partner, coordinated end-to-end by Twig.
On-site, local anesthesia
PESA
Percutaneous Epididymal Sperm Aspiration
Sperm is aspirated from the epididymis using a fine needle, typically under local anesthesia. The first-line surgical option for obstructive azoospermia.
On-site, local anesthesia
TESA
Testicular Sperm Aspiration
Sperm is aspirated directly from the testicle, also under local anesthesia. Considered when PESA is not viable or when testicular sperm is preferred.
Hospital, general anesthesia
microTESE
Microsurgical Testicular Sperm Extraction
For non-obstructive azoospermia, where sperm production itself is severely impaired. Performed at a hospital with our surgical partner; Twig coordinates the surgical date, sample transport, and IVF cycle timing.
Fertility preservation
Sperm Freezing
Worth considering before cancer treatment (chemotherapy and radiation can permanently affect sperm production), before a surgical procedure that could affect fertility, or simply to preserve your current sperm quality on your own timeline. Frozen on-site in our cryostorage facility with RI Witness electronic tracking.
$600 includes the first 3 months of storage. Ongoing cryostorage is $800/year in Toronto, $900/year in Vancouver.
Optimizing Sperm Health
What you do today, shows up in three months.
Lifestyle factors that matter
- Nicotine (smoking and vaping)
Tobacco and vapor products reduce sperm count, concentration, motility, and morphology, and increase DNA fragmentation. Even cutting back helps. Stopping helps more.
- Cannabis
Linked to lower sperm counts, concentration, and motility, and to erectile dysfunction. If you’re trying to conceive, our recommendation is to stop.
- Alcohol
Moderate to heavy consumption is linked to decreased semen volume and impaired motility. Minimize during the months before conception or fertility treatment.
- Scrotal heat
Hot tubs, saunas, prolonged laptop use on the lap, and heated car seats can elevate scrotal temperature and impair sperm production. Worth avoiding in the months before treatment.
- Exercise and weight
Regular physical activity is associated with better semen parameters. Obesity is linked to lower concentration, lower motility, and higher DNA fragmentation, in part because additional scrotal tissue increases heat exposure.
- Anabolic steroids and testosterone
Will suppress sperm production and cause testicular atrophy, sometimes for years. Avoid if you’re planning a family. Also be cautious with protein supplements: some contain undisclosed amounts of anabolic steroids.
- Diet
A Mediterranean-style diet (vegetables, healthy fats from olive oil, nuts, and seeds, whole grains, legumes, fruit, fish and poultry over red meat) is the best-studied dietary pattern for sperm health.
Sperm cells have a 2 to 3 month life cycle. Lifestyle changes you make now will show up in test results a season from now. Most sperm providers can meaningfully improve sperm parameters in a single quarter.

Evidence-based supplementation
Antioxidant supplementation may improve sperm parameters, particularly in cases with elevated oxidative stress. Supplements should be started at least 3 months before conception or treatment to align with the sperm life cycle.
Choose third-party tested products. Be cautious with herbal supplements due to limited evidence and inconsistent regulation.
Key supplements
- Co-Enzyme Q10
- L-Carnitine
- L-Arginine
- Resveratrol
- N-Acetyl Cysteine
Suggested brands
- Bird&Be Power Prenatal for Sperm with CoQ10 Boost
- Flow Vita
- Fertil Pro MEN + Fertil Pro MTL
or speak to a naturopath at Flourish for personalized advice.
Advanced Sperm Age
A different conversation about age and sperm.
There’s no single age that defines advanced sperm age, but research suggests that risks begin to gradually increase around age 40. Most children born to older sperm providers are healthy. Some risks have been identified in research, and we believe in being honest about them.
Genetic conditions
As sperm ages, there’s a slight increase in new genetic variants that arise during sperm development (not inherited from either parent). These variants can cause rare conditions including achondroplasia, thanatophoric dysplasia, craniosynostosis syndromes, multiple endocrine neoplasia (MEN 2A/B), and Noonan or Costello syndromes. The overall risk of having a child with one of these conditions is less than 0.5%. There’s no pre-pregnancy screening for these conditions; the detailed anatomy ultrasound at 18 to 20 weeks gestation can screen for some of them.
Neurodevelopmental and psychiatric conditions
There’s a known association between older sperm age and increased risk of autism spectrum disorders, schizophrenia, and bipolar disorder. These conditions are complex, involving genetics, environment, and chance. There’s no genetic screening available, but awareness and early support can help if challenges arise later.
Pregnancy and infant health
There’s some evidence of weak associations between advanced sperm age and slightly higher risks of congenital anomalies, pregnancy loss, and pregnancy complications. The associations are weak.
Aneuploidy (chromosome differences)
Some evidence links advanced sperm age to slightly higher aneuploidy risk, but the connection with egg age is much stronger. Standard prenatal screening for chromosomal differences is available to every pregnant person in Canada.
If you’re a sperm provider over 40 considering family building, we can discuss your specific picture and any options that may be relevant.
Our Reproductive Urologists
The team for the surgical side.
Twig has reproductive urologists on staff who perform PESA and TESA on-site, rather than referring out. For complex cases requiring microTESE, we coordinate the surgical date and sample transport with our hospital-based partner.
Diagnostic Pricing
Transparent pricing for testing.
Treatment pricing (IVF, IUI, surgical retrieval) is on our full pricing page. Diagnostics for sperm providers are below.
| Test | Toronto | Vancouver |
|---|---|---|
| Fertility Check for Sperm (includes semen analysis + virtual specialist review) | $250 | $250 |
| Semen Analysis (standalone) | Covered by OHIP | $150 |
| Sperm Freezing (first 3 months storage included) | $600 | $600 |
| Sperm DNA Fragmentation | Done via FlowLabs* | $400 |
| Genetic Carrier Screening | $600 | $600 |
| PESA / TESA (surgical sperm retrieval) | Quoted at consult | Quoted at consult |
Sperm DNA Fragmentation Index in Toronto is performed by FlowLabs; fees payable directly to FlowLabs. Prices subject to change.
Common Questions
Answers, plainly.
For most patients, the simplest entry point is a Fertility Check for Sperm. It includes a full semen analysis and a 20-minute virtual review with one of our fertility specialists, plus a personalized report. It’s $250 in both Toronto and Vancouver, requires no referral, and gives you a clear baseline. If your results suggest further evaluation, your specialist will guide you to the right next step, whether that’s a Family Building Consult or deeper diagnostic workup. You can book directly through our website.
A few things. Our Toronto and Vancouver labs both perform ICSI, PICSI, and sperm freezing in-house. We have a reproductive urologist on staff who performs surgical sperm retrievals (PESA and TESA) on-site, rather than referring out. For complex cases requiring microTESE at a hospital, we coordinate the surgical date and the sample transport so the experience stays seamless. Most Canadian fertility clinics handle the IVF side but refer out the surgical urology piece. We don’t.
The first step is a fertility consult with one of our specialists. A semen analysis gives a snapshot in time, but the right next step depends on the full picture: hormone levels, medical history, lifestyle, and the reproductive picture of the person you’re planning to conceive with. We’ll review the data and discuss what’s most likely to help: lifestyle changes, medication, IUI, IVF with ICSI, or further specialized testing.
IVF (in vitro fertilization) is the cycle that combines eggs with sperm in our lab to create embryos. ICSI (intracytoplasmic sperm injection) is a specific fertilization technique used during IVF, where one sperm is injected into each egg. ICSI dramatically improves fertilization when sperm counts or motility are low. PICSI is a refinement of ICSI that uses hyaluronic acid to select more mature sperm with intact DNA, which may help patients with elevated DNA fragmentation or recurrent early pregnancy losses.
Sperm regenerate on a 2 to 3 month cycle, so changes you make now show up in a semen analysis about a season later, and most sperm providers can meaningfully improve their parameters in a single quarter. The biggest levers: stop smoking and vaping, cut back or stop cannabis, minimize alcohol, avoid scrotal heat (hot tubs, saunas, laptops on the lap), stay active and keep a healthy weight, avoid anabolic steroids and testosterone, and eat a Mediterranean-style diet. Antioxidant supplements like CoQ10 and L-carnitine, started at least three months ahead, may help, especially with elevated oxidative stress. Your Twig team can pinpoint what's worth changing for your specific picture.
About 2 to 3 months. That’s the length of the sperm life cycle. Lifestyle changes you make today (better sleep, less alcohol, better diet, more exercise, less heat exposure) will be reflected in a semen analysis a season from now. The corollary is that the sperm in today’s ejaculate reflect the past 3 months of your life.
Most children born to older sperm providers are healthy. Research suggests risks begin to gradually increase around age 40, with weak associations to slightly higher rates of certain conditions. The risk of a child with one of the rare genetic conditions associated with sperm age is less than 0.5%. If you’re a sperm provider over 40 considering family building, we can discuss your specific picture during your initial consult.
Surgical sperm retrieval recovers sperm directly from the epididymis or the testicle in cases of obstructive azoospermia (a blockage preventing sperm from reaching the ejaculate) or severe ejaculatory dysfunction. The two main on-site procedures are PESA (aspiration from the epididymis) and TESA (aspiration from the testicle). Both are minimally invasive, performed under local anesthesia, and take place at the Twig clinic with a reproductive urologist on staff. For more complex cases (non-obstructive azoospermia), microTESE is performed at a hospital with our coordination.
Sperm freezing is worth considering if you’re starting cancer treatment (chemo and radiation can permanently affect sperm production), if you’re undergoing a surgical procedure that could affect fertility, if your current job involves prolonged exposure to fertility-affecting environments, or if you’re planning a family later in life and want to preserve current sperm quality. Sperm freezing at Twig is $600 and includes the first 3 months of storage; ongoing cryostorage is $800/year in Toronto, $900/year in Vancouver.
Some diagnostic tests are covered by OHIP in Ontario, including semen analysis, hormone testing, and infectious disease screening. DNA fragmentation tests are typically not covered. In British Columbia, MSP covers some baseline tests, but self-pay applies for many sperm-specific tests. The Ontario Fertility Tax Credit covers 25% of eligible expenses up to $5,000 per year. Funded IVF cycles are available to eligible Ontario residents.
Get Started
Ready to talk to a specialist?
Just curious about your fertility? Start with a Fertility Check for Sperm.
